Dapoxetine 30mg Tablet

Three studies9,12,13 including 2950 patients compared the PGIC in dapoxetine 30 mg and placebo subgroups

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A statistically significant difference was found in the subgroup treated with 30 mg dapoxetine compared with the placebo-treated group (MD = 1.16; 95% CI = 0.94–1.38; P < 0.00001). The subgroup analysis of the dapoxetine group treated with 60 mg compared with placebo also reporting IELT also revealed a statistically significant difference in patient response (MD = 1.63; 95% CI = 1.41–1.84; P < 0.00001). In addition, five studies9,12,13,14,15 including a total of 3346 patients, we pooled to compare IELT; patients were divided into two groups treated with either 60 mg or 30 mg dapoxetine. In the fixed-effect model meta-analysis of the five studies, the pooled estimates were statistically significantly different between the dapoxetine 60 mg and 30 mg groups (MD = 0.39; 95% CI = 0.23–0.56; P < 0.00001; Figure 4). This pooled analysis indicated that the dapoxetine 60 mg group was associated with a markedly longer IELT than the dapoxetine 30 mg group. and four studies9,10,12,13 including 3567 patients compared PGIC in dapoxetine 60 mg and a placebo subgroup.

Pooled analysis indicated that when compared to the placebo group, there was a significantly higher proportion of PGIC in the dapoxetine group.

Ethics declarations

The use of Dapoxetine tablets has been associated with ocular effects such as mydriasis and eye pain. Dapoxetine tablets should be used with caution in patients with raised intraocular pressure or those at risk of angle closure glaucoma. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Side Effects Common Poxet Side effects include Feeling dizzy, Headache, Feeling sick, Feeling irritable, anxious, agitated or restless, Feeling numb or having 'pins and needles', Difficulty getting or keeping an erection, Sweating more than normal or flushing, Diarrhoea, constipation or having wind, Stomach pain, bloating or being sick, Problems sleeping or strange dreams, Feeling tired or sleepy, yawning, Blocked nose (nasal congestion), A rise in blood pressure, Difficulty concentrating, Shaking or trembling, Lower interest in sex, Ringing in the ears, Blurred vision, Indigestion and Dry mouth. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Tablets Overdose Symptoms of overdose with SSRIs like Poxet (Generic Dapoxetine Hydrochloride Tablets) include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness.

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In cases of Poxet overdose, standard supportive measures should be taken as required. Due to high protein binding and large volume of distribution of Dapoxetine HCl, forced diuresis, dialysis, hemoperfusion and exchange transfusion are not likely to be of any benefit. No specific antidotes for Poxet are known at present. © Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) Poxet Tablets During Pregnancy Dapoxetine Hydrochloride (Poxet Tablets) has been classified by the US FDA as Pregnancy Category C. Poxet Tablets are not indicated for use by women.

Short Duration

© Clearsky Pharmacy( ) Poxet (Generic Dapoxetine Hydrochloride Tablets) For more details on Poxet Tablets click here Poxet (Dapoxetine Hydrochloride Tablets) by Sunrise Remedies Private Limited, India. The tablet has a bitter taste, so swallow it whole without chewing. Dapoxetine is not intended for regular daily use – you should only take it before you anticipate having sex. Take them to your local pharmacy which will dispose of them for you. If you have any problems with the way your liver works, or if you have any problems with the way your kidneys work. The overall risk ratio (RR) was 2.14 (95% CI = 1.90–2.42; P < 0.00001).

• Dapoxetine 30mg tablets help improve control over ejaculation in many users.
• The onset of action usually occurs within 30 to 60 minutes after ingestion.
• Effects last for approximately 4 to 6 hours post-dose.
• Not a treatment for erectile dysfunction, only premature ejaculation.
• Should not be combined with nitrates or alpha-blockers due to low blood pressure risk.
• Avoid operating machinery if dizziness or drowsiness develops after taking dapoxetine.
• Inform your healthcare provider if you have liver or kidney disease.
• Report any allergic reactions or severe side effects immediately.

The subgroup analysis indicated a statistically significant difference between the dapoxetine (for both 30 mg and 60 mg groups) and the placebo group in PGIC (RR = 2.01, 95% CI = 1.69–2.38, P < 0.00001; and RR = 2.26, 95% CI = 1.91–2.67, P < 0.00001, respectively; Figure 5).

What Is Dapoxetine 30mg?

The role of PE on the individual and the sexual relationship is very significant. Thus, it is important to treat patients with PE in order to improve quality of life. At present, treatment of PE includes mainly psychotherapy, drug therapy and surgical treatment6. Drug therapy is not only likely to be the most receptive approach for patients, but it is also the most commonly used method. Selective serotonin reuptake inhibitors (SSRIs) have become the most widely used medicine in the world7.

Molecular Weight

Dapoxetine hydrochloride, belonging to the class of SSRIs, was the first drug originally approved for the on-demand treatment of men with PE by seven European countries in 20088. Unfortunately, the efficacy and safety of dapoxetine (30 mg and 60 mg on-demand) has never been comprehensively studied in men with PE. Most data derived from clinical studies in men with PE are available. The objective of this study was to not only evaluate the efficacy and safety of dapoxetine when used at either 30 mg or 60 mg as compared with the placebo as an oral on-demand treatment in men with PE in routine clinical practice by performing a meta-analytic synthesis of studies, but also to assess whether there are differences in efficacy and safety for PE treatment using either 30 mg or 60 mg dapoxetine. The electronic dapoxetine 60 mg tablets and manual searches of PubMed, EMBASE and Cochrane Central Register of Controlled Trials (Cochrane Library) databases resulted in 106 references, of which 88 were clearly not relevant to our study.

Premature ejaculation

Of the remaining 18 references, 11 were excluded after reading the full text. After a quality validation, only seven studies9,10,11,12,13,14,15 were selected from the literature search. The flow chart of the evidence acquisition process is summarized in Figure 1 and the methodological quality of the included studies is reported in Figure 2. Seven randomized controlled trials (RCTs) involving 8039 PE patients met the inclusion criteria. Of these, 2478, 2932 and 2629 patients received 30 mg dapoxetine, 60 mg dapoxetine, or the placebo, respectively. In addition, data from three9,12,13 studies reporting PGIC compared dapoxetine dosages (60 mg versus 30 mg).

Safety Assessments

The study included patients aged 18 years or older and the patients were randomized for dapoxetine 30 mg or dapoxetine 60 mg or placebo administration on-demand (1–3 hours prior to anticipated sexual activity). The basic characteristics of the included studies are summarized in Table 1. Three of the RCTs selected9,12,13 evaluating dapoxetine versus placebo for PE reported IELT as the primary outcome. Our pooled analysis showed that PE in patients in the dapoxetine group showed a significant improvement in IELT when compared to patients in the placebo group (mean difference [MD] = 1.39; 95% confidence interval [95% CI] = 1.24–1.55; P < 0.00001). Among these studies, we carried out a subgroup analysis based on PE patients treated with dapoxetine 30 mg and 60 mg on-demand oral administration. These count data were extracted to perform a forest plot analysis, which showed that the use of dapoxetine 60 mg was associated with a

significantly greater improvement in PGIC than when dapoxetine 30 mg was used (RR = 1.17, 95% CI = 1.09–1.25; P < 0.00001, Figure 6).

• Dapoxetine 30mg tablets are not suitable for patients with severe liver impairment.
• Use caution in patients with mild to moderate kidney issues; consult a physician.
• It is important to disclose all allergies to your healthcare provider.
• Switching from other SSRIs to dapoxetine requires proper medical guidance.
• Inform your doctor if you experience prolonged erection or pain.
• The tablet’s effect varies individually; some may need dosage adjustments.
• Psychological counseling can complement dapoxetine for best treatment outcomes.
• Dapoxetine should not be used as an aphrodisiac or performance enhancer.

Data from four9,11,12,13 and five9,10,11,12,13 studies reported AEs with sufficient data to generate a subgroup

forest plot for dapoxetine 30 mg versus placebo and dapoxetine 60 mg versus placebo, respectively.

Benefits of Dapoxetine 30mg

The recommended starting dose is one 30 mg tablet, taken 1 to 3 hours before you anticipate having sex.Each tab dapoxetine 30 mg film-coated tablet contains dapoxetine hydrochloride equivalent to 30 mg or 60 mg dapoxetine. The most common AE was nausea and occurred in %, % and % of subjects with placebo, dapoxetine 60 mg and dapoxetine mg respectively. This medication is used to treat male sexual dysfunction such as premature ejaculation. The effectiveness of the drug will not be . Premature ejaculation (PE) is the most common male sexual dysfunction.

Brand Names

Dapoxetine hydrochloride, belonging to a class of drugs known as selective serotonin reuptake inhibitors or, was the first drug originally approved for the on-demand treatment of men with PE. We aimed to compare the intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC) and adverse effect (AE) incidence associated with the use of dapoxetine (30 mg and 60 mg) versus placebo and evaluate the differences in administering 60 mg versus 30 mg as on-demand medical oral therapy for the treatment of PE via a literature review and meta-analysis. Relevant randomized controlled trials (RCTs) were identified from PubMed, EMBASE and Cochrane Central Register of Controlled Trials (Cochrane Library) databases. Ultimately, a total of seven RCTs with 8039 patients were included. Our meta-analysis demonstrated that dapoxetine (in the 30 mg and 60 mg subgroup) resulted in significantly higher IELT, PGIC and AE incidence relative to the placebo, with higher proportions observed for 60 mg versus 30 mg of dapoxetine administration.

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The most common AEs were mild and tolerable. We conclude that dapoxetine (particularly the 60 mg dosage) may be considered a safe and effective drug for patients with PE. Premature ejaculation (PE) is the most common male sexual dysfunction with a prevalence of between 20% and 40%1,2. Recently, the International Society for Sexual Medicine has proposed the following evidence-based definition: “PE is a male sexual dysfunction characterized by ejaculation that always or nearly always occurs prior to or within about 1 minute of vaginal penetration; inability to delay ejaculation on all or nearly all vaginal penetrations; and negative personal consequences, such as distress, bother, frustration, and/or the avoidance of sexual intimacy”3,4. In addition, PE affects numerous aspects of a man's life, including sexual confidence, interpersonal relationships and the sexual satisfaction of both partners5.