Steven Kaplan, MD, Highlights Faster-Acting Sildenafil Oral Spray for Erectile Dysfunction

Studies show it’s as effective as tablets for treating erectile dysfunction.

Clinical trials have shown that a 50mg dose of

Key Takeaways

In this video, Steven A. Kaplan, MD, shares What we did in this study is to look at what happened in terms of pure absorption. So, these were patients who were given either 4 mL sildenafil oral jelly 100mg of the suspension vs 100 mg of sildenafil. What we found is that there was a faster absorption. I mean significantly faster absorption, which is what we hoped and what we thought.

6.2 Postmarketing Experience

But it's kind of nice when you do the study and it actually happens. There was a higher average amount in the bloodstream compared to Viagra tablets. So, this is not generic, it's the Viagra tablets itself. That suggested to us [and] it's reasonable to assume that this suspension is absorbed more quickly. In addition, the average levels of the medication in the bloodstream, at least during the first 30 minutes, was higher.

Sildenafil Oral Suspension Dosage and Administration

So, our thought process that if you deliver it that way, as a spray under your tongue, it would be absorbed faster, came out. It's always nice when you have a hypothetical concept and then all of a sudden, you do it clinically, and then it's working. The data wasn't like, "Well..." No, it's pretty clear. It starts getting absorbed in 5 minutes, and that is much faster than we see with Viagra. This transcription has been edited for clarity. sildenafil was effective in 74% of people, while a

lower 25mg dose was 62% effective, and the highest

Product introduction

Not all treatments work on their first go. Combining ED medication with healthy lifestyle changes, having a health check with your GP and trying therapy for emotional or mental health causes can all improve your ED. Keep an open mind and we can help you find the most suitable treatment for you.” – Dr Sameer Sanghvi For more information on the possible side effects of Hezkue and correct use, please read the patient information leaflet. Please let your GP know if you experience any side effects while using Hezkue. Like any treatment, you may experience side effects when taking Hezkue.

13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility

Very common side effects (may affect more than 1 in 10 people) Common (may affect up to 1 in 10 people) Changes to sight (colour perception, blurred vision) Uncommon (may affect up to 1 in 100 people) Changes to heart rate and blood pressure Pain in upper abdomen, arms or legs Rare (may affect up to 1 in 1000 people) Changes to sight including spots in vision *Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). Initial absorption of HEZKUE®/BANDOL® (100 mg of sildenafil) was observed within 5 minutes after administration (0.615 ng/mL, p = 0.012) vs Viagra® 100 mg tablets that showed no absorption at that time. It will be available other markets upon approval. Our initial product is a proprietary oral suspension formulation of sildenafil citrate, the active ingredient in VIAGRA® currently available in Spain as BANDOL® and available across all other geographies as HEZKUE®. Please visit our country specific websites below: Fast absorption after just 5 minutes compared to Viagra® tablets2* *Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil).

Sprays vs. Pills

Fast absorption after just 5 minutes compared to Viagra® tablets2* *Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). With personalized dosing, HEZKUE®/BANDOL® is tailored to the users’ individual needs and lifestlyes and eliminates the need for planning.2 HEZKUE®/BANDOL® is bioequivalent to Viagra® tablets, offering a safe and effective alternative for treating ED.2 Delivers the same efficacious dose as Viagra®2* *Compared to Viagra® 100 mg tablets and well-established safety profile for sildenafil used in the treatment of ED. ** With respect to AUC, measured after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). 2024.1 #Data based on mean plasma concentration after application of 8 pumps of HEZKUE®/BANDOL® (100 mg of sildenafil) compared to Viagra® tablets (100 mg sildenafil). Initial absorption of HEZKUE®/BANDOL® (100 mg of sildenafil) was observed within 5 minutes after administration (0.615 ng/mL) while Viagra® 100 mg tablets showed no absorption at that time.1 Viagra® (sildenafil) is a drug marketed in Spain by Viatris Pharmaceuticals S.L.( Initial absorption of HEZKUE®/BANDOL® was observed within 5 minutes after administration while Viagra® tablets showed no absorption at that time.1 Prospective, open-label, single-centre, two-way crossover comparative bioavailability study in 56 healthy male volunteers in fasting conditions. 100mg dose was 82% effective compared to a placebo.

Quick tips

The biggest difference between sildenafil spray and tablets, like Viagra, is the way they are administered. Hezkue spray is a faster and more convenient alternative to traditional ED pills. Some of the key benefits of Hezkue spray over sildenafil tablets include: no need to take it with water easier for anyone who finds it difficult to take tablets Hezkue works the same in the same way as other sildenafil products like Viagra and phosphodiesterase type 5 (PDE-5) inhibitors in that it increases blood flow to the penis, helping you to get and maintain an erection. It does this by relaxing the smooth muscle cells in the blood vessels in the penis, allowing the blood flow in your penis to increase. Unlike tablets, Hezkue spray is absorbed directly into your bloodstream through your mouth. A study investigating the effects of a sildenafil oral spray in

14. Clinical Studies

HEZKUE®/BANDOL® is bioequivalentto sildenafil tablets*2 HEZKUE®/BANDOL® is a safe and effective alternative for ED2 *The Pharmacokinetic study showed that HEZKUE®/BANDOL® was found bioequivalent to Viagra® tablet with respect to sildenafil systemic exposure, as reflected in the 90% confidence intervals for AUClast and AUC∞. HEZKUE®/BANDOL® and Viagra® tablet were not bioequivalent with respect to Cmax, with a modestly higher maximum sildenafil concentration for HEZKUE®/BANDOL®.1 Anti-Anxiety Medications, Anti-Depressants & Sleeping Pills5 In young men, it is usually undervalued and attributed to psychological problems6 HEZKUE®/BANDOL® is a ready-to-use sildenafil suspension spray. See HEZKUE®/BANDOL® product information (as of May 2024). Study UNICO: Perception of Urologists and Andrologists, in Spain, about the Use of Sildenail Oral Suspension in Patients with Erectile Dysfunction. Opinions, Attitudes, and Perceptions in Relation to Erectile Dysfunction and Premature Ejaculation in the Undiagnosed Spanish Male Population.

How long does Hezkue spray take to work?

2001;166(2):569-74. discussion 574-5. Rastrelli G, Maggi M. Erectile dysfunction in fit and healthy young men: psychological or pathological? Aspargo Labs is in the process of bringing the most important Rx and OTC medicines to market as oral suspensions.

Does sildenafil interact with other medicines (drug interactions)?

Jesse Ory, MD Clinical Instructor and Urologist at the University of Miami “The nice thing with this is you can titrate up pretty easily without having to break up a bunch of pills and try and be your own pharmacist." "The problem is there’s so there hasn’t been anything new, really, in ED for at least 10, 20 years, ...truly new that that is being used by everyone...but guys are going out and just getting anything they can that is different.” Hossein Mirheydar, MDUrologist in Baldwin Park, California Kaiser Permanente “I think this product definitely looks like an exciting opportunity, in terms of the rapid onset of activity and also the utilization of a non-oral, GI-absorbing treatment. I would invite all my patients of all ages, to try an oral spray Sildenafil.” Dr. Laurence A. Levine, MDProfessor of Urology Department of Urology at Rush University Medical Center, Chicago “I think in general the concept of something oral … that you can just simply spray in your mouth really easily, and don’t have to worry about a pill and all the rest, I think is attractive.” “In addition, the average levels of the medication in the bloodstream, at least during the first 30 minutes, was higher,” says Steven A. Kaplan, MD. people with type 2 diabetes and prediabetes found that it reduced

12. Sildenafil Oral Suspension - Clinical Pharmacology

Kaplan is a member of the medical advisory board for Aspargo Labs. Hezkue suspension is an oral sildenafil spray that can effectively treat erectile dysfunction. Fast absorption within 5 minutes compared to Viagra tablets. Flexible dosing: Each bottle contains up to 20 doses (25 mg), 10 doses (50 mg), or 5 doses (100 mg). No pills required – easy-to-swallow liquid with mint flavour.

Hezkue side effects

Hezkue is a branded prescription-only oral sildenafil spray that is quickly absorbed into the bloodstream and can provide fast, effective relief from erectile dysfunction. The active ingredient, sildenafil, is the same as Viagra, but it is provided in an oral spray. Hezkue works by increasing blood flow to your penis, so when you are sexually aroused, it is easier to get and maintain an erection. Studies show sildenafil sprays are as effective as tablets. And, previous trials have shown that 74% of people reported improvements in their erectile function with a 50mg dose tablet.

Sprays vs. Supplements

If Hezkue sounds like a suitable ED treatment for you, you can request it directly from Superdrug Online Doctor by completing a short online questionnaire for one of our doctors to review. If your request is approved, you can choose rapid home delivery in plain, discreet packaging, or you can collect it from your nearest Superdrug Pharmacy. Hezkue is a sildenafil suspension oral spray that is used to treat erectile dysfunction (ED). It contains the same active ingredient as Viagra, called sildenafil, but Hezkue can be used in place of ED pills. Hezkue spray is a prescription-only medication, which means you will need approval from a doctor before you can obtain it. body weight, waist circumference, insulin, and HbA1c levels in those with type 2 diabetes and effectively

• Sildenafil spray offers a non-invasive alternative to injections.
• It promotes blood flow to the penile area.
• The onset of action is usually faster than tablets.
• It is an option for men who dislike swallowing pills.
• The spray may reduce gastrointestinal discomfort.
• Consistent use without medical advice is discouraged.
• Dose titration might be necessary for effectiveness.
• It may be used in combination with other ED treatments.
• Possible side effects include nasal congestion or dizziness.
• Proper storage extends the shelf life of the spray.
• Contact a healthcare provider if adverse effects occur.

improved erectile dysfunction in both groups.

• Sildenafil spray is a topical form used for erectile dysfunction treatment.
• It offers quick absorption due to its spray formulation.
• Typically, sildenafil spray acts faster than oral tablets.
• The spray is applied under the tongue for rapid effect.
• Dosage varies depending on individual health and response.
• It is important to follow prescribed instructions for safety.
• Sildenafil spray may cause side effects like headache or flushing.
• It should not be used with nitrates or certain medications.
• Long-term safety data on sildenafil spray is limited.
• It is prescribed by a healthcare professional.
• Always store sildenafil spray in a cool, dry place.