20 Mg Vardenafil

Other > vardenafil 5 mg


Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.

Vardenafil side effects

clarithromycin and vardenafil both increase QTc interval. danazoldanazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. danazol will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. doxazosinvardenafil increases effects of doxazosin by pharmacodynamic synergism. vardenafil increases effects of doxazosin by pharmacodynamic synergism.

How is vardenafil supplied (dosage forms)?

entrectinib and vardenafil both increase QTc interval. eribulin and vardenafil both vardenafil canada increase QTc interval. Avoid coadministration of fexinidazole with drugs known to block potassium channels and/or prolong QT interval. givinostatvardenafil and givinostat both increase QTc interval. If unable to avoid coadministration, obtain ECGs when initiating, during concomitant use, and as clinically indicated. If coadministration of a QTc prolonging drug is unavoidable, monitor for increased risk of QTc interval prolongation. macimorelinmacimorelin and vardenafil both increase QTc interval. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Avoid coadministration with drugs that prolong QT interval, which could increase risk for developing torsade de pointes-type ventricular tachycardia.

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Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. macimorelin and vardenafil both increase QTc interval. mefloquinemefloquine increases toxicity of vardenafil by QTc interval.

Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. mefloquine increases toxicity of vardenafil by QTc interval. vardenafil and milsaperidone both increase QTc interval. moxisylytevardenafil increases effects of moxisylyte by pharmacodynamic synergism. vardenafil increases effects of moxisylyte by pharmacodynamic synergism. ondansetronondansetron and vardenafil both increase QTc interval. ondansetron and vardenafil both increase QTc interval. oxaliplatin and vardenafil both increase QTc interval. phenoxybenzaminevardenafil increases effects of phenoxybenzamine by pharmacodynamic synergism. vardenafil increases effects of phenoxybenzamine by pharmacodynamic synergism. phentolaminevardenafil increases effects of phentolamine by pharmacodynamic synergism. vardenafil increases effects of phentolamine by pharmacodynamic synergism. prazosinvardenafil increases effects of prazosin by pharmacodynamic synergism. vardenafil increases effects of prazosin by pharmacodynamic synergism.

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Withhold if QTc interval >500 ms or a change from baseline >60 ms. vardenafil and givinostat both increase QTc interval. hydroxychloroquine sulfate and vardenafil both increase QTc interval. idelalisibidelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates idelalisib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

What are the most common side effects of vardenafil?

Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates iloperidonevardenafil and iloperidone both increase QTc interval. isoflurane and vardenafil both increase QTc interval. itraconazoleitraconazole and vardenafil both increase QTc interval. itraconazole and vardenafil both increase QTc interval. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. ribociclibribociclib increases toxicity of vardenafil by QTc interval. ribociclib increases toxicity of vardenafil by QTc interval. rifabutinrifabutin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. rifabutin will decrease the level or effect of vardenafil blue pillmen by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Other Comments

buprenorphine subdermal implantbuprenorphine subdermal implant and vardenafil both increase QTc interval. buprenorphine subdermal implant and vardenafil both increase QTc interval. buprenorphine transdermalbuprenorphine transdermal and vardenafil both increase QTc interval. buprenorphine transdermal and vardenafil both increase QTc interval. buprenorphine, long-acting injectionbuprenorphine, long-acting injection and vardenafil both increase QTc interval.

Erectile Dysfunction

buprenorphine, long-acting injection and vardenafil both increase QTc interval. carbamazepinecarbamazepine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. carbamazepine will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ceritinib and vardenafil both increase QTc interval. clarithromycinclarithromycin and vardenafil both increase QTc interval. rifampinrifampin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Parameter Value Notes
Absorption Rate Fast Peak plasma concentration in ~1 hour
Bioavailability Approximately 15% Due to first-pass metabolism
Half-Life About 4-5 hours Time for plasma levels to reduce by half
Metabolism Primarily hepatic via CYP3A4 Liver enzyme responsible

rifampin will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Storage Condition Recommended Temperature Light & Moisture Protection Shelf Life
In a cool, dry place 15-30°C (59-86°F) Keep in tightly sealed container 2-3 years from manufacture date
Keep out of reach of children Yes Yes
Avoid exposure to humidity No Store away from sunlight

sevofluranesevoflurane and vardenafil both increase QTc interval. sevoflurane and vardenafil both increase QTc interval. silodosinvardenafil increases effects of silodosin by pharmacodynamic synergism. vardenafil increases effects of silodosin by pharmacodynamic synergism. siponimod and vardenafil both increase QTc interval. St John's WortSt John's Wort will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Shipping & Delivery

asenapineasenapine and vardenafil both increase QTc interval. asenapine and vardenafil both increase QTc interval. asenapine tadalis sx 20 mg transdermalasenapine transdermal and vardenafil both increase QTc interval. asenapine transdermal and vardenafil both increase QTc interval. Either increases effects of the other by Other (see comment).

How should I store vardenafil?

Comment: Avoid combination; duplicate therapy is not recommended. buprenorphinebuprenorphine and vardenafil both increase QTc interval. buprenorphine and vardenafil both increase QTc interval. buprenorphine buccalbuprenorphine buccal and vardenafil both increase QTc interval. buprenorphine buccal and vardenafil both increase QTc interval. St John's Wort will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

terazosinvardenafil increases effects of terazosin by pharmacodynamic synergism. vardenafil increases effects of terazosin by pharmacodynamic synergism. tetrabenazinetetrabenazine and vardenafil both increase QTc interval. tetrabenazine and vardenafil both increase QTc interval. tovorafenibtovorafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of tovorafenib (a weak CYP3A4 inducer) with CYP3A substrates where minimal concentration changes may lead to serious therapeutic failures. If unavoidable, monitor patients for loss of efficacy unless otherwise recommended in the CYP3A4 substrate prescribing information.

What other drugs will affect vardenafil?

vardenafil increases effects of nitroglycerin rectal by additive vasodilation. Either increases effects of the other by additive vasodilation. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension. Either increases effects of the other by pharmacodynamic synergism. Coadministration of vericiguat with PDE-5 inhibitors may result in additive hypotensive effects.

Semantic Clinical Drug (SCD): Vardenafil 5 mg Oral Tablet (Atom ID: 1543052)

Either increases effects of the other by QTc interval. Each drug prolongs the QTc interval, which may increased the risk of Torsade de pointes, other serious arryhthmias, and sudden death. If coadministration unavoidable, more frequent monitoring is recommended for such patients. alfuzosinvardenafil increases effects of alfuzosin by pharmacodynamic synergism. vardenafil increases effects of alfuzosin by pharmacodynamic synergism. tovorafenib will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Concept Hierarchy & Relationship Mapping

amisulprideamisulpride and vardenafil both increase QTc interval. amisulpride and vardenafil both increase QTc interval. anagrelide and vardenafil both increase QTc interval. apalutamideapalutamide will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications.

Incidence not known

Avoid or substitute another drug for these medications when possible. Evaluate for loss of therapeutic effect if medication must be coadministered. Adjust dose according to prescribing information if needed. apalutamide will decrease the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. artemether and vardenafil both increase QTc interval. tucatinibtucatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. If unavoidable, reduce CYP3A substrate dose according to product labeling. tucatinib will increase the level or effect of vardenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. vardenafil increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval.

Aspect Description Typical Dosage Onset Time Duration of Action
Vardenafil 5 mg A medication used to treat erectile dysfunction 5 mg 30-60 min Up to 4-5 hours
Pharmacological Class Phosphodiesterase type 5 inhibitor N/A N/A N/A
Brand Names Levitra, Staxyn (dissolvable film) N/A N/A N/A

Concomitant use of vemurafenib with drugs that prolong QT interval is not recommended. vilanterol/fluticasone furoate inhaledvardenafil increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval.

vardenafil increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval.