Cautionary note: stimulants in the bedroom

The chart below breaks down the cost of Wisp’s OMG! Cream as both a one-time purchase and a subscription (charged and shipped every three months). Similar to competitors like Promescent, opting for recurring deliveries from Wisp will reduce your cost per bottle. Competitor Hello Cake offers a similar topical, O-Cream Rx For Her, that’s available in either regular (1% sildenafil) or extra strength (3% sildenafil). For example, a 12-dose order of regular strength O-Cream Rx is $108 — that’s nearly $70 more than a one-time purchase of a 15-dose bottle of OMG! And since the products from both companies contain at least 1% sildenafil, there doesn’t appear to be a dose-dependent reason for this significant price difference. Cream contains 15 treatments only if you adhere to Wisp’s instructions to use a pea-sized amount.

The Goods Inside

One small study from 2015 found that long-term (eight weeks) intranasal oxytocin (32UI) self-administered by women 50 minutes before sexual intercourse improved both sexual function and symptoms of depression.68 And a 2023 study in men receiving testosterone treatment for erectile dysfunction found that oxytocin troches (50-100UI) may be a helpful adjunctive treatment, with 56% of patients (14 out of 26) considered responders to the intervention.69 In contrast to the short ingredient list of Libido Lift Rx, Drive For Her contains seven herbal ingredients and one amino acid. Here’s how their potential benefits for female sexual health break down. A 2015 study evaluated how Libifem affected sex hormones and sexual function in 80 healthy, menstruating women with self-reported low libido. Participants in the treatment group (600mg per day for eight weeks) experienced a “significant increase” in blue 100 pill free testosterone and estradiol, as well as sexual arousal and desire versus the placebo group.73 Other, unrelated research on fenugreek extract found similar results. A 2021 study gave 48 healthy, menstruating women either 250mg of fenugreek extract twice a day or a placebo.

Fast onset, flexible use

Those who took the extract had fewer sexual problems and reduced irritability, along with increased estradiol, free testosterone, and total testosterone.74 The evidence on reishi mushrooms for female sexual dysfunction or libido support is pretty slim, with only a couple of animal studies available at this time. In a 2018 study, male Wistar rats were either given one of two reishi extracts (150mg/kg and 300mg/kg) or one of two placebos (sildenafil and distilled water) to evaluate the mushroom’s aphrodisiac potential. Results showed that the lower dose of 150mg/kg was more effective, but, in general, the reishi extract increased the rats’ interest in females and led to increased mounting behavior and mating performance.75 A similar male rat study from 2022 found that reishi mushroom polysaccharides may be able to treat diabetes mellitus-induced erectile dysfunction (DMED), in part by enhancing “the mRNA expression of” nitric oxide synthase (the enzyme that turns L-arginine to L-citrulline and nitric oxide).76 77 This ingredient has the least amount of scientific support. In a 2007 overview of guarana’s history and prospects, researchers state that this plant “has been distorted by market forces into an aphrodisiac and energy booster.”78 This is supported by the findings of a few small studies. A 2009 study gave breast cancer patients 75mg daily for 28 days and found that there were no effects on radiation-induced fatigue or depression.79 And an older study that gave 45 elderly volunteers 1g of guarana found no significant sleep quality, cognitive, or sexual improvements.80 While there isn’t much research on caffeine for female sexual health, the results of a 2023 study showed that, compared to a placebo, acute administration of 300mg of caffeine (around six times the amount in this supplement) increased genital arousal in women experiencing sexual dysfunction due to antidepressants.81 There are a few positive studies that suggest saffron supplementation may be beneficial for sexual dysfunction. Using any more or less than the suggested quantity can alter the number of uses you get out of a bottle — and how often you need to reorder.

While Wisp’s subscriptions do net you a nice 10-15% discount, we wish the shipping intervals could be modified. Everyone’s situation is unique, and it’s not difficult to imagine someone needing refills of this cream more or less often than every quarter. And though you do have the option to request an early refill or pause your subscription as needed, it would be nice to see the company add some subscription customization options in the future to make the process more convenient from the outset for customers with different needs.

When purchasing from Wisp, your telehealth visit for prescriptions — like OMG! Cream — is included with the medication cost. And if you have an HSA/FSA account, you can either use a card at checkout or download the necessary documents for reimbursement. (Wisp doesn’t accept insurance at this time, but that’s not all that unusual in the telehealth space.) Additionally, shipping is discreet and always free. However, due to the nature of Wisp’s products, the company does not accept returns or offer refunds. Only if you receive a product in error and contact Wisp within 15 days of receipt will the company investigate the situation and issue a replacement product if deemed appropriate. To learn more about Wisp and the platform’s telehealth visit process, check out our full Wisp review.

The Big Pink Fight for the Little Pink Pill

Libido Lift Rx is unique in that it’s the fildena tablet first fast-acting libido-support prescription pill for women that we’ve come across, as of this writing. Most other options on the market are supplements or either prescription or non-prescription topicals. So, as mentioned previously, this dissolvable tablet may be the closest thing to an “instant” female arousal pill, since it should start working in around 30 minutes. If you’re suffering from a form of female sexual dysfunction, like hypoactive sexual desire disorder (HSDD), Libido Lift Rx will not get to the root of the problem. According to experts, HSDD appears to be caused by an imbalance of certain neurotransmitters and hormones in the brain, which the ingredients in Libido Lift Rx won’t affect.18 Pivoting to the supplement, Hello Cake Drive For Her (previously called “Sex Drive For Her”) is a blend of various herbal ingredients and L-arginine intended to increase sexual desire.

Is it safe?

While there is some supportive research behind most of this supplement’s ingredients, the evidence isn’t quite as strong as it is for VitaFLUX’s nitric-oxide-boosting amino acids. But, if you can’t take a supplement with such a heavy focus on increasing nitric oxide — or if you simply prefer the idea of an herbal supplement and its potential benefits — then Drive For Her is an option worth considering. (As a side note, Drive For Her only requires you to take two capsules daily instead of VitaFLUX’s six.) In addition to Libido Lift Rx and the Drive For Her supplement, it’s worth mentioning that Cake also offers a topical arousal product similar to Wisp’s OMG Cream called “O-Cream Rx for Her.” Both creams include the same 1% concentration of sildenafil (the generic form of Viagra). However, Cake’s prescription is more expensive than Wisp’s for fewer applications. But, unlike Wisp, Cake does offer an extra strength option containing 3% sildenafil, though that’s even pricier. Best prescription pill and runner-up OTC pill Oral tadalafil (generic Cialis) for women is a fairly specialized offering Libido Lift Rx should work in around 30 minutes and last 24-36 hours Prescription “pills” are actually mint-flavored tablets that dissolve under the tongue Drive For Her supplement ingredients have some supportive research Drive For Her subscriptions take 15% off 10% off prescription treatments using code INNERBODY10 Both are unsafe for those who are pregnant or breastfeeding Supplement may contain traces of all nine major allergens Supplements likely require extended use, contrary to product page information More research needed on both tadalafil and oxytocin for FSD “For Her” meds can’t ship to Alabama, California, South Carolina, fildena 200 mg Guam, or Puerto Rico Hello Cake (often stylized as just “Cake”) is a telehealth company focused on sexual health. While the brand offers a wide range of products intended to improve your sexual well-being, we chose its Cake Meds Libido Lift Rx and Hello Cake Drive For Her as our picks for the best prescription pill and runner-up OTC pill.

• Libido pills may contain ingredients like hormonal precursors to increase arousal.
• Some natural supplements are marketed as libido boosters without scientific backing.
• Possible side effects of libido pills include nausea, dizziness, or hormonal imbalance.
• Women should consider underlying health issues before using libido-enhancing medications.

Libido Lift Rx is unique in that it’s the fildena tablet first fast-acting libido-support prescription pill for women that we’ve come across, as of this writing. Most other options on the market are supplements or either prescription or non-prescription topicals.

• Some libido pills claim to improve blood flow to enhance arousal in women.
• Hormonal therapy might be prescribed for women with menopause-related low libido.
• Avoid unregulated supplements due to potential contaminants or false claims.
• Regular exercise and adequate sleep can naturally improve women's sexual desire.

So, as mentioned previously, this dissolvable tablet may be the closest thing to an “instant” female arousal pill, since it should start working in around 30 minutes. If you’re suffering from a form of female sexual dysfunction, like hypoactive sexual desire disorder (HSDD), Libido Lift Rx will not get to the root of the problem.

Product Information

According to experts, HSDD appears to be caused by an imbalance of certain neurotransmitters and hormones in the brain, which the ingredients in Libido Lift Rx won’t affect.18 Pivoting to the supplement, Hello Cake Drive For Her (previously called “Sex Drive For Her”) is a blend of various herbal ingredients and L-arginine intended to increase sexual desire. While there is some supportive research behind most of this supplement’s ingredients, the evidence isn’t quite as strong as it is for VitaFLUX’s nitric-oxide-boosting amino acids. But, if you can’t take a supplement with such a heavy focus on increasing nitric oxide — or if you simply prefer the idea of an herbal supplement and its potential benefits — then Drive For Her is an option worth considering. (As a side note, Drive For Her only requires you to take two capsules daily instead of VitaFLUX’s six.) In addition to Libido Lift Rx and the Drive For Her supplement, it’s worth mentioning that Cake also offers a topical arousal product similar to Wisp’s OMG Cream called “O-Cream Rx for Her.” Both creams include the same 1% concentration of sildenafil (the generic form of Viagra).

However, Cake’s prescription is more expensive than Wisp’s for fewer applications.

Desire Starts in the Brain...

At this time, we’d only recommend opting for Cake’s O-Cream Rx for Her if you’ve tried a 1% sildenafil topical, found it wasn’t strong enough for your needs, and would like to try the 3% sildenafil extra strength variety. That said, let’s examine the ingredients in Libido Lift Rx and Drive For Her. Libido Lift Rx has a fairly small list of ingredients, containing only L-citrulline, oxytocin, and tadalafil. Let’s cover how this prescription’s inclusions work. The research on tadalafil for women is pretty sparse, but the results that exist are promising.

Upcoming Events

As noted in a 2017 review on phosphodiesterase type 5 (PDE5) inhibitors for FSD in older women,70 research has mainly focused on tadalafil for women with FSD due to antidepressants or diabetes.71 72 Both studies (using 5-20mg tadalafil) led to positive outcomes — all patients experienced improvement — but were limited by small sample sizes and lack of placebo control. As researchers continue to investigate the effects of PDE5 inhibitors in women, we’ll update this guide accordingly. Since L-citrulline gets converted in the body to L-arginine and nitric oxide, supplementing with this amino acid may lead to increased nitric oxide production.10 There really isn’t any research on oral L-citrulline supplementation alone for female sexual dysfunction or libido support, but some research on men found that 1,500mg could help treat mild to moderate erectile dysfunction.20 However, that’s nearly eight times the amount in Libido Lift Rx. But, to be fair, the L-citrulline in this prescription appears to play more of a supporting role than a main one. There’s very little research on oxytocin as a treatment for sexual dysfunction. But, unlike Wisp, Cake does offer an extra strength option containing 3% sildenafil, though that’s even pricier.

Customer Reviews

The chart below breaks down the cost of Wisp’s OMG! Cream as both a one-time purchase and a subscription (charged and shipped every three months). Similar to competitors like Promescent, opting for recurring deliveries from Wisp will reduce your cost per bottle. Competitor Hello Cake offers a similar topical, O-Cream Rx For Her, that’s available in either regular (1% sildenafil) or extra strength (3% sildenafil). For example, a 12-dose order of regular strength O-Cream Rx is $108 — that’s nearly $70 more than a one-time purchase of a 15-dose bottle of OMG!

Thank you for subscribing!

And since the products from both companies contain at least 1% sildenafil, there doesn’t appear to be a dose-dependent reason for this significant price difference. Cream contains 15 treatments only if you adhere to Wisp’s instructions to use a pea-sized amount. Using any more or less than the suggested quantity can alter the number of uses you get out of a bottle — and how often you need to reorder. While Wisp’s subscriptions do net you a nice 10-15% discount, we wish the shipping intervals could be modified. Everyone’s situation is unique, and it’s not difficult to imagine someone needing refills of this cream more or less often than every quarter. At this time, we’d only recommend opting for Cake’s O-Cream Rx for Her if you’ve tried a 1% sildenafil topical, found it wasn’t strong enough for your needs, and would like to try the 3% sildenafil extra strength variety.

From $99.70/mo

And though you do have the option to request an early refill or pause your subscription as needed, it would be nice to see the company add some subscription customization options in the future to make the process more convenient from the outset for customers with different needs. When purchasing from Wisp, your telehealth visit for prescriptions — like OMG! Cream — is included with the medication cost. And if you have an HSA/FSA account, you can either use a card at checkout or download the necessary documents for reimbursement. (Wisp doesn’t accept insurance at this time, but that’s not all that unusual in the telehealth space.) Additionally, shipping is discreet and always free.

Medications for HSDD

However, due to the nature of Wisp’s products, the company does not accept returns or offer refunds. Only if you receive a product in error and contact Wisp within 15 days of receipt will the company investigate the situation and issue a replacement product if deemed appropriate. To learn more about Wisp and the platform’s telehealth visit process, check out our full Wisp review. Best prescription pill and runner-up OTC pill Oral tadalafil (generic Cialis) for women is a fairly specialized offering Libido Lift Rx should work in around 30 minutes and last 24-36 hours Prescription “pills” are actually mint-flavored tablets that dissolve under the tongue Drive For Her supplement ingredients have some supportive research Drive For Her subscriptions take 15% off 10% off prescription treatments using code INNERBODY10 Both are unsafe for those who are pregnant or breastfeeding Supplement may contain traces of all nine major allergens Supplements likely require extended use, contrary to product page information More research needed on both tadalafil and oxytocin for FSD “For Her” meds can’t ship to Alabama, California, South Carolina, fildena 200 mg Guam, or Puerto Rico Hello Cake (often stylized as just “Cake”) is a telehealth company focused on sexual health. While the brand offers a wide range of products intended to improve your sexual well-being, we chose its Cake Meds Libido Lift Rx and Hello Cake Drive For Her as our picks for the best prescription pill and runner-up OTC pill. That said, let’s examine the ingredients in Libido Lift Rx and Drive For Her.

Libido Lift Rx has a fairly small list of ingredients, containing only L-citrulline, oxytocin, and tadalafil. Let’s cover how this prescription’s inclusions work. The research on tadalafil for women is pretty sparse, but the results that exist are promising. As noted in a 2017 review on phosphodiesterase type 5 (PDE5) inhibitors for FSD in older women,70 research has mainly focused on tadalafil for women with FSD due to antidepressants or diabetes.71 72 Both studies (using 5-20mg tadalafil) led to positive outcomes — all patients experienced improvement — but were limited by small sample sizes and lack of placebo control.

• Male and female libido pills differ; women’s products typically focus on hormonal and nerve health.
• Overuse of libido pills can lead to psychological dependence or expectations.
• Women experiencing persistent low libido should seek medical evaluation.
• Lifestyle factors, partner intimacy, and mental health are key components of desire.

As researchers continue to investigate the effects of PDE5 inhibitors in women, we’ll update this guide accordingly. Since L-citrulline gets converted in the body to L-arginine and nitric oxide, supplementing with this amino acid may lead to increased nitric oxide production.10 There really isn’t any research on oral L-citrulline supplementation alone for female sexual dysfunction or libido support, but some research on men found that 1,500mg could help treat mild to moderate erectile dysfunction.20 However, that’s nearly eight times the amount in Libido Lift Rx.

• Some pills target hormonal balance to address low libido in women.
• Risks of libido pills include interactions with other medications or health conditions.
• It’s vital to discuss with a doctor to find the root cause of low libido before medication.
• Monitoring side effects during treatment helps ensure safe and effective use.

But, to be fair, the L-citrulline in this prescription appears to play more of a supporting role than a main one. There’s very little research on oxytocin as a treatment for sexual dysfunction. One small study from 2015 found that long-term (eight weeks) intranasal oxytocin (32UI) self-administered by women 50 minutes before sexual intercourse improved both sexual function and symptoms of depression.68 And a 2023 study in men receiving testosterone treatment for erectile dysfunction found that oxytocin troches (50-100UI) may be a helpful adjunctive treatment, with 56% of patients (14 out of 26) considered responders to the intervention.69 In contrast to the short ingredient list of Libido Lift Rx, Drive For Her contains seven herbal ingredients and one amino acid. Here’s how their potential benefits for female sexual health break down. A 2015 study evaluated how Libifem affected sex hormones and sexual function in 80 healthy, menstruating women with self-reported low libido. Participants in the treatment group (600mg per day for eight weeks) experienced a “significant increase” in blue 100 pill free testosterone and estradiol, as well as sexual arousal and desire versus the placebo group.73 Other, unrelated research on fenugreek extract found similar results. A 2021 study gave 48 healthy, menstruating women either 250mg of fenugreek extract twice a day or a placebo. Those who took the extract had fewer sexual problems and reduced irritability, along with increased estradiol, free testosterone, and total testosterone.74 The evidence on reishi mushrooms for female sexual dysfunction or libido support is pretty slim, with only a couple of animal studies available at this time. In a 2018 study, male Wistar rats were either given one of two reishi extracts (150mg/kg and 300mg/kg) or one of two placebos (sildenafil and distilled water) to evaluate the mushroom’s aphrodisiac potential. Results showed that the lower dose of 150mg/kg was more effective, but, in general, the reishi extract increased the rats’ interest in females and led to increased mounting behavior and mating performance.75 A similar male rat study from 2022 found that reishi mushroom polysaccharides may be able to treat diabetes mellitus-induced erectile dysfunction (DMED), in part by enhancing “the mRNA expression of” nitric oxide synthase (the enzyme that turns L-arginine to L-citrulline and nitric oxide).76 77 This ingredient has the least amount of scientific support. In a 2007 overview of guarana’s history and prospects, researchers state that this plant “has been distorted by market forces into an aphrodisiac and energy booster.”78 This is supported by the findings of a few small studies.

Women okay with injections

A 2009 study gave breast cancer patients 75mg daily for 28 days and found that there were no effects on radiation-induced fatigue or depression.79 And an older study that gave 45 elderly volunteers 1g of guarana found no significant sleep quality, cognitive, or sexual improvements.80 While there isn’t much research on caffeine for female sexual health, the results of a 2023 study showed that, compared to a placebo, acute administration of 300mg of caffeine (around six times the amount in this supplement) increased genital arousal in women experiencing sexual dysfunction due to antidepressants.81 There are a few positive studies that suggest saffron supplementation may be beneficial for sexual dysfunction.